medicinal chemistry

Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with drug designdesigning and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entitynew chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR).Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, molecular biology, statistics, and physical chemistry.

Process of drug discovery -

Discovery - The first step of drug discovery involves the identification of new active compounds, often called "hits", which are typically found by screening many compounds for the desired biological properties. These hits can come from natural sources, such as plants, animals, or fungi. More often, the hits can come from synthetic sources, such as historical compound collections and combinatorial chemistry.Recent developments in robotics and miniaturization have greatly accelerated and automated the screening process. Typically, a company will assay over 100,000 individual chemical compoundcompounds before moving to the optimization step.

Optimization - The second step of drug discovery involves the synthetic modification of the hits in order to improve the biological properties of the compound pharmacophore. The quantitative structure-activity relationship of the pharmacophore play an important part in finding "lead compounds", which exhibit the most potency, most selectivity, and least toxicity.See also: ADME and Lipinski's Rule of Five''

Development - The final step involves the rendering the "lead compounds" suitable for use in clinical trials. This involves the optimization of the Chemical synthesissynthetic route for bulk production, and the preparation of a suitable drug formulation.

See also -

Pharmacology

!List_of_publications_in_chemis try#Medicinal? chemistryImportant publications in medicinal chemistry

Pharmacophore

External links -

bentham.org - Current Medicinal Chemistry

pubs.acs.org - Journal of Medicinal Chemistry

efmc.info - European Federation for Medicinal ChemistryBranchesofChemistry Category:Medicinal chemistry ar:كيمياء صيدلانيةca:Química !Farmacèuticade:Pharmazeutisch e? !Chemieth:เคมีเภส ัชภัณฑ์zh:药物 化学

Contract Research Organization
Global CINRG is a technology-driven global pharmaceutical, biotechnology and medical decide product development company combining a global CRO with a multinational ARO-SMO, uniform SOPs and uniform technology.
http://www.globalcinrg.com/

American Chemical Society Publications
Publishes products and services for the practice and advancement of the chemical sciences.
http://pubs.acs.org/

ScienceDirect
Research papers published on the net , subscription required for some sections.
http://www.sciencedirect.com